- After his managing contract with the Cincinnati Reds expired in 1894, Charles Comiskey decided to try ownership by buying the Sioux City Cornhuskers. The team was transferred to Saint Paul, Minnesota where the Cornhuskers played for five seasons.

- In 1900, Charles Comiskey moved his team to the South Side of Chicago and renamed the team the White Stockings.

- In 1901, the White Stockings win first American League major league pennant.

- In 1904, headline editors at the Chicago Tribune sports department began shortening the name to "White Sox", and the team officially adopted the shorter name.

- In 1906, the White Sox were known as the "Hitless Wonders," with a team batting average of just .230. The team overcame its struggles with pitching (2.13 team ERA) and faced the crosstown rival Cubs in the World Series. The White Sox went on to win the series four games to two.

- In 1910, Comiskey Park opens on July 1st replacing the 39th Street Grounds where the White Sox played from 1900-1910.

- In 1917, the White Sox posted a record of 100-54, a franchise record for wins and winning percentage. The White Sox went on to win the World Series against the New York Giants four games to two.

- In 1919, the Cincinnati Reds beat the heavily favorite White Sox five games to three in the World Series. Word spread that gamblers bribed White Sox players into losing in exchange for cash. The following year, eight White Sox players were charged to conspiring to fix the outcome of the World Series. This event became known as the "Black Sox Scandal".

- In 1920, the White Sox pitching staff was the first in the majors to feature four 20-game winners.

- In 1922, Rookie pitcher Charlie Robertson threw a perfect game against the Detroit Tigers. He became the first pitcher in major league history to throw a perfect game on the road.